- Chemical Name 2-(4-CHLORO-PHENYL)-3-OXO-BUTYRONITRILE
- CAS No. 5219-07-8
- Contact Us Inquiry
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1.What is the 2-(4-CHLORO-PHENYL)-3-OXO-BUTYRONITRILE ?
Used in Pharmaceutical Industry:
2-(4-CHLORO-PHENYL)-3-OXO-BUTYRONITRILE is used as a key intermediate for the synthesis of various pharmaceuticals, particularly anti-cancer and anti-bacterial agents, due to its ability to be transformed into a wide range of compounds.
Used in Organic Compounds Synthesis:
2-(4-CHLORO-PHENYL)-3-OXO-BUTYRONITRILE is used as a versatile building block in the production of various organic compounds, contributing to the formation of complex chemical structures.
-
-
141-78-6
ethyl acetate
-
-
140-53-4
p-chlorobenzyl cyanide
-
-
5219-07-8
2-(4-chlorophenyl)-3-oxobutanenitrile
| Conditions | Yield |
|---|---|
|
With
sodium;
at 80 ℃;
for 14h;
|
68%
|
|
ethyl acetate; p-chlorobenzyl cyanide;
With
sodium;
for 4h;
Reflux;
With
hydrogenchloride; water;
|
65%
|
|
Multistep reaction;
(i) NaH, DMSO, (ii) /BRN= 506104/;
|
|
|
With
sodium;
Heating;
|
|
|
p-chlorobenzyl cyanide;
With
sodium hydride;
In
tetrahydrofuran;
ethyl acetate;
In
tetrahydrofuran;
|
|
|
With
sodium hydride;
In
tetrahydrofuran;
at 0 - 60 ℃;
|
|
|
p-chlorobenzyl cyanide;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
for 0.0833333h;
ethyl acetate;
In
tetrahydrofuran; mineral oil;
at 60 ℃;
|
-
-
75-36-5
acetyl chloride
-
-
140-53-4
p-chlorobenzyl cyanide
-
-
5219-07-8
2-(4-chlorophenyl)-3-oxobutanenitrile
| Conditions | Yield |
|---|---|
|
p-chlorobenzyl cyanide;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 0.166667h;
acetyl chloride;
In
tetrahydrofuran;
at -78 ℃;
Further stages.;
|
|
|
p-chlorobenzyl cyanide;
With
lithium diisopropyl amide;
Inert atmosphere;
acetyl chloride;
Inert atmosphere;
|
2.What is the CAS number for 2-(4-CHLORO-PHENYL)-3-OXO-BUTYRONITRILE ?
The CAS number of 2-(4-CHLORO-PHENYL)-3-OXO-BUTYRONITRILE is 5219-07-8.
More information of 2-(4-CHLORO-PHENYL)-3-OXO-BUTYRONITRILE 5219-07-8 are:
|
CAS?Number |
5219-07-8 |
|
Density |
1.221g/cm3 |
|
Boiling Point |
274.9°Cat760mmHg |
|
Flash Point |
120°C |
|
Vapor Pressure |
0.00527mmHg at 25°C |
|
Refractive Index |
1.542 |
|
HS CODE |
2926909090 |
|
PSA |
40.86000 |
|
LogP |
2.53618 |
3.What are another words for 2-(4-CHLORO-PHENYL)-3-OXO-BUTYRONITRILE ?
Synonyms?for?2-(4-CHLORO-PHENYL)-3-OXO-BUTYRONITRILE 5219-07-8:Acetoacetonitrile,2-(p-chlorophenyl)- (6CI,8CI); 2-(p-Chlorophenyl)acetoacetonitrile;p-Chlorophenylacetoacetonitrile
4.What is the molecular formula of 2-(4-CHLORO-PHENYL)-3-OXO-BUTYRONITRILE?
The chemical formula of ?2-(4-CHLORO-PHENYL)-3-OXO-BUTYRONITRILE is?C10H8 Cl N O which containing 10 Carbon atoms,8 Hydrogen atoms,1 Chlorine atoms,1 Nitrogen atoms and 1 Oxygen atoms,and the molecular weight of??2-(4-CHLORO-PHENYL)-3-OXO-BUTYRONITRILE?is 193.633.
5.What is 2-(4-CHLORO-PHENYL)-3-OXO-BUTYRONITRILE (5219-07-8) used for?
2-(4-CHLORO-PHENYL)-3-OXO-BUTYRONITRILE, also known as 4-chlorophenylacetoacetonitrile, is a chemical compound with the molecular formula C10H7ClNO. It is a white to off-white crystalline powder that is commonly used in the synthesis of pharmaceuticals and organic compounds. This versatile building block is known for its role as an intermediate in the synthesis of various pharmaceuticals, including anti-cancer and anti-bacterial agents.
InChI:InChI=1/C10H8ClNO/c1-7(13)10(6-12)8-2-4-9(11)5-3-8/h2-5,10H,1H3/t10-/m0/s1
Relevant articles related to 2-(4-CHLORO-PHENYL)-3-OXO-BUTYRONITRILE:
|
Article |
Source |
|
N -Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK |
Pippione, Agnese C.,Sainas, Stefano,Federico, Antonella,Lupino, Elisa,Piccinini, Marco,Kubbutat, Michael,Contreras, Jean-Marie,Morice, Christophe,Barge, Alessandro,Ducime, Alex,Boschi, Donatella,Al-Karadaghi, Salam,Lolli, Marco L. supporting information, p. 963 - 968 (2018/06/27) |
|
HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK |
- Page/Page column 52, (2012/11/08) |
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