- Chemical Name 4-Fluorobenzanilide
- CAS No. 366-63-2
- Contact Us Inquiry
Factory Supply industrial standard 4-Fluorobenzanilide 366-63-2 In Stock
- Molecular Formula: C13H10FNO
- Molecular Weight: 215.227
- Vapor Pressure: 0.014mmHg at 25°C
- Melting Point: 182-184 °C
- Boiling Point: 258.1°Cat760mmHg
- PKA: 13.39±0.70(Predicted)
- Flash Point: 109.9°C
- PSA: 29.10000
- Density: 1.247g/cm3
- LogP: 3.15100
4-Fluorobenzanilide(Cas 366-63-2) Usage
|
General Description |
4-Fluorobenzanilide, also known as 4-fluoro-N-phenylbenzamide, is an organic compound that consists of a fluorine atom attached to a benzene ring, and an amide group bonded to the phenyl ring. It is a white solid that is sparingly soluble in water but dissolves in organic solvents. 4-Fluorobenzanilide is commonly used as an intermediate in the production of pharmaceuticals and other organic compounds. It has also been studied for its potential use in organic synthesis and medicinal chemistry applications. Additionally, it has been investigated for its potential pharmacological properties, including its role as a potential analgesic or anti-inflammatory agent. |
InChI:InChI=1/C13H10FNO/c14-11-8-6-10(7-9-11)13(16)15-12-4-2-1-3-5-12/h1-9H,(H,15,16)
366-63-2 Relevant articles
Design, Synthesis, and Pharmacological Activity of a New Matrix Metalloproteinase-9 Inhibitor
Grigorkevich,Mokrov,Dyabina,Stolyaruk,Tsorin,Ionova,Kryzhanovskii,Gudasheva,Durnev
, p. 30 - 36 (2018)
The new MMP-9 inhibitor 1-{4-[(4-chlorob...
Visible-Light-Promoted Iron-Catalyzed N-Arylation of Dioxazolones with Arylboronic Acids
Tang, Jing-Jing,Yu, Xiaoqiang,Yamamoto, Yoshinori,Bao, Ming
, p. 13955 - 13961 (2021/11/20)
A visible-light-promoted and simple iron...
Regioselective Synthesis of 2° Amides Using Visible-Light-Induced Photoredox-Catalyzed Nonaqueous Oxidative C-N Cleavage of N, N-Dibenzylanilines
Neerathilingam, Nalladhambi,Bhargava Reddy, Mandapati,Anandhan, Ramasamy
supporting information, p. 15117 - 15127 (2021/10/25)
A visible-light-driven photoredox-cataly...
Iron-catalyzed oxidative amidation of acylhydrazines with amines
Wang, Yi-Jie,Zhang, Guo-Yu,Shoberu, Adedamola,Zou, Jian-Ping
, (2021/08/18)
A new approach for amide bond formation ...
Metal-free transamidation of benzoylpyrrolidin-2-one and amines under aqueous conditions
Joseph, Devaneyan,Lee, Sunwoo,Park, Myeong Seong
supporting information, p. 6227 - 6232 (2021/07/28)
N-Acyl lactam amides, such as benzoylpyr...
366-63-2 Process route
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-
347-84-2
1-(4-fluorophenyl)-2-phenylethanone
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-
62-53-3
aniline
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-
366-63-2
4-fluoro-N-phenylbenzamide
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-
100-52-7
benzaldehyde
| Conditions | Yield |
|---|---|
|
With
1,10-Phenanthroline; copper(II) chloride dihydrate; oxygen;
In
acetonitrile;
for 36h;
under 760.051 Torr;
Reflux;
|
67%
98 %Chromat. |
-
-
459-57-4
4-fluorobenzaldehyde
-
-
62-53-3
aniline
-
-
366-63-2
4-fluoro-N-phenylbenzamide
| Conditions | Yield |
|---|---|
|
With
bis(1,5-cyclooctadiene)nickel (0); 2,2,2-Trifluoroacetophenone; 1,3-bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene;
In
1,4-dioxane;
at 40 ℃;
for 8h;
Inert atmosphere;
Glovebox;
|
97%
|
|
aniline;
With
C12H30NaO6(1+)*C56H84O4Sm(1-);
In
tetrahydrofuran;
for 0.5h;
Inert atmosphere;
4-fluorobenzaldehyde;
In
tetrahydrofuran;
at 25 ℃;
for 3h;
Inert atmosphere;
|
82%
|
|
aniline;
With
C24H48KO6(1+)*C108H152KLa2O12(1-);
for 0.5h;
Inert atmosphere;
4-fluorobenzaldehyde;
at 25 ℃;
for 22h;
Inert atmosphere;
|
79%
|
|
aniline;
With
C56H86F2Li2N3O4Si2Sm;
In
tetrahydrofuran;
at 25 ℃;
for 0.5h;
Inert atmosphere;
Glovebox;
4-fluorobenzaldehyde;
In
tetrahydrofuran;
at 25 ℃;
for 3h;
Inert atmosphere;
Glovebox;
|
74%
|
|
With
tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide;
In
acetonitrile;
at 80 ℃;
for 6h;
|
71%
|
|
aniline;
With
C58H92La2N6O4Si4;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
Inert atmosphere;
4-fluorobenzaldehyde;
In
tetrahydrofuran;
for 3h;
Inert atmosphere;
|
71%
|
|
4-fluorobenzaldehyde;
With
potassium carbonate;
In
neat (no solvent);
at 85 ℃;
for 0.333333h;
aniline;
In
neat (no solvent);
at 85 ℃;
|
43%
|
366-63-2 Upstream products
-
658-13-9
p-fluorobenzoyl cyanide
-
62-53-3
aniline
-
403-43-0
4-fluorobenzoyl chloride
-
462-06-6
fluorobenzene
366-63-2 Downstream products
-
871123-22-7
(C6 H5 NHCOC6 H4 )2CCH3 C6 H4 NH2 (OC6 H4 )2
-
397-54-6
2-(4-fluorophenyl)benzoxazole
-
1449384-25-1
N-cyclopropyl-4-fluoro-N-phenylbenzamide
-
459-56-3
4-fluorobenzylic alcohol