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  • Chemical Name 2-Chloropyrazine
  • CAS No. 14508-49-7
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Top quality factory supply 14508-49-7 2-Chloropyrazine at low price

  • Molecular Formula: C4H3ClN2
  • Molecular Weight: 114.534
  • Appearance/Colour: clear colorless to yellowish liquid 
  • Vapor Pressure: 3.92mmHg at 25°C 
  • Melting Point: 153～154℃ 
  • Refractive Index: n20/D 1.539(lit.)  
  • Boiling Point: 155.3 °C at 760 mmHg 
  • PKA: -1.10±0.10(Predicted) 
  • Flash Point: 57 °C 
  • PSA： 25.78000 
  • Density: 1.303 g/cm3 
  • LogP: 1.13000 

2-Chloropyrazine(Cas 14508-49-7) Usage

Purification Methods

Fractionally distil it through a short column packed with glass helices. It has apenetrating, mildly pungent odour with a high vapour pressure at room temperature. [Erickson & Spoerri J Am Chem Soc 68 400 1946, Hetman & O.Donnell J Org Chem 28 1682 1963, Beilstein 23/5 V 366.]

Application

2-Chloropyrazine is used as a reagent in the synthesis of hetaryloxy benzoxaborole compounds which have antimalarial activity. 2-Chloropyrazine is also used to prepare 4,5-disubstituted 6-aryloxy-1,3-dihydrobenzo[c][1,2]oxaboroles which are broad-spectrum serine β-lactamase inhibitors.

InChI:InChI=1/C4H3ClN2/c5-4-3-6-1-2-7-4/h1-3H

14508-49-7 Relevant articles

Synthesis, crystal structures, and properties of the copper(I) halide coordination polymers ∞2[CuX(μ-2-chloropyrazine-N,N′)] (X = Cl, Br), ∞1[CuI(2-chloropyrazine-N)], and [Cu2I2(2-chloropyrazine)]

Naether, Christian,Wriedt, Mario,Je, Inke

, p. 394 - 400 (2002)

The new copper coordination polymers ∞2[...

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Busby et al.

, p. 1344 (1969)

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Studies on Pyrazines. 11. A Novel Formation of 2-Aminopyrazine from the Reaction of Pyrazine 1-Oxide with Phosphoryl Chloride

Sato, Nobuhiro,Kobayashi, Michio

, p. 3015 - 3016 (1984)

-

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Konakahara,Takagi

, p. 2734,2738, 2739 (1977)

-

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Cheeseman

, p. 242,246 (1960)

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Efficient Phosphorus-Free Chlorination of Hydroxy Aza-Arenes and Their Application in One-Pot Pharmaceutical Synthesis

Wang, Jian,Li, Yan-Hui,Pan, Song-Cheng,Li, Ming-Fang,Du, Wenting,Yin, Hong,Li, Jing-Hua

supporting information, p. 146 - 153 (2020/03/10)

The chlorination of hydroxy aza-arenes w...

Preparation method of 2, 6-dichloropyrazine

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Paragraph 0034; 0038-0039; 0047-0052, (2020/04/22)

The invention discloses a preparation me...

SUBSTITUTED ARYLPYRAZINES

-

, (2008/06/13)

Arylpyrazine compounds are provided, inc...

14508-49-7 Process route

1-methyl-1H-imidazole
616-47-7

1-methyl-1H-imidazole

chloroform
67-66-3,8013-54-5

chloroform

2-chloropyrazin
14508-49-7

2-chloropyrazin

5-chloropyrimidine
17180-94-8

5-chloropyrimidine

2-cyano-5-chloropyridine
89809-64-3

2-cyano-5-chloropyridine

5-chloronicotinonitrile
51269-82-0

5-chloronicotinonitrile

Conditions
Conditions Yield
at 550 ℃; Yield given. Further byproducts given. Yields of byproduct given;
3-chloropyrazine 1-oxide
6863-76-9

3-chloropyrazine 1-oxide

2-chloropyrazin
14508-49-7

2-chloropyrazin

2,5-dichloropyrazine
19745-07-4

2,5-dichloropyrazine

2,3-dichloropyrazine
4858-85-9

2,3-dichloropyrazine

2,6-dichloropyrazine
4774-14-5

2,6-dichloropyrazine

Conditions
Conditions Yield
With trichlorophosphate; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;

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    1H-imidazole

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    chloroform

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